MK Waqas1,
N Akhtar1,
A Rasul2,
SU Rashid3,
R Mustafa1,
BA Khan4,
G Murtaza5 
For correspondence:- Murtaza Email: gmdogar356@gmail.com Tel:+00923142082826
Received: 10 May 2014 Accepted: 6 August 2014 Published: 24 September 2014
Citation: Waqas M, Akhtar N, Rasul A, Rashid S, Mustafa R, Khan B, et al. In vivo Evaluation of a Cosmetic Emulsion Containing Soybean Extract for Anti-Aging. Trop J Pharm Res 2014; 13(9):1401-1406 doi: 10.4314/tjpr.v13i9.4
© 2014 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To develop and assess the anti-aging potential of a cosmetic W/O emulsion containing an extract of soybean, Glycine max (L.) Merr. Fabaceae.
Methods: This single-blind placebo-controlled study was performed in 11 healthy male human volunteers. A formulation comprising of 4 % of concentrated extract of soybean was prepared by loading the extract in the internal aqueous phase of the emulsion. A control (base), consisting of the emulsion without the extract, was also prepared. Both formulations were applied to the cheeks of all volunteers for 12 weeks and their effect on different skin parameters, i.e., moisture contents, elasticity and surface evaluation of living skin (SELS) were assessed.
Results: The formulation containing 4 % soybean extract showed significant (p ≤ 0.05) effects on skin elasticity and moisture contents but the base showed insignificant effect (p > 0.05). There was significant (p ≤ 0.05) decline in SELS, i.e., SEsc (skin scaliness, from 1.73 ± 0.05 to 1.66 ± 0.06), SEw (skin wrinkles, from 71.74 ± 1.52 to 68.51 ± 1.64), SEsm (skin smoothness, from 109.01 ± 4.77 to 102.03 ± 4.23), and SEr (skin roughness, from 4.04 ± 0.09 to 3.82 ± 0.08) parameters after application of the extract formulation for 12 weeks.
Conclusion: Topical application of the cosmetic emulsion containing soybean extract exerts potential skin anti-aging effects.
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